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Is electronic cigarette oil poisonous? Scientific lies need to be exposed with science!


Although the composition of cigarette oil is very simple, it is mainly composed of propylene glycol, glycerin, nicotine, flavors and additives. The ingredients are also common in daily life, such as food, beverages and other products, but the same food-grade materials are eaten and inhaled after heating and atomization Will there be a difference afterwards? This is also the question of many people, and it will often become the gripper of attacking e-cigarettes.

Ceramic Cartridge Vape Pen

Ceramic Cartridge Vape Pen

And this kind of "rumors" that is not supported by science is harmful to e-cigarettes. For example, in the early "popcorn lung" incident, although there is only one case and it cannot be proven that the cause is due to the ingredients in e-cigarette oil , But at the time, it destroyed a well-known brand of cigarette oil, and since then collapsed.

As a result, a new "conjecture" came into being, that is, even if the components of e-cigarette oil are safe and widely used in the food and beverage industry, some flavors or additives may not be eaten. Causes harm to the body, but after heating and atomization, is it safe? Who knows?

This hypothetical theory of "harmful flavoring ingredients" has also contributed to the "e-cigarette taste ban". Even among e-cigarette users, there have been rumors to try not to use certain flavors to prevent poison.

In 2017, a targeted study in Europe seemed to confirm this "conjecture" scientifically.

"European Breath" Magazine: Carcinogens of Electronic Cigarette

In 2017, a survey report was published in the "European Breath" magazine to study the effects of the ingredients in the e-cigarette supplement liquid (liquid oil) on the human body.

The project was launched with the funding of the European Commission. In 2016, within 9 EU member states, the five most popular brands were identified based on brand data, sales data or website data, questionnaires, etc. Three products were randomly selected from the complete product list of all the five brands for chemical analysis, and the total number of test samples reached 122.

The samples were analyzed by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) methods, and the results were compared with the Globally Harmonized Classification System (GHS) classification of respiratory tract irritants.

A total of 246 different fragrances and additives were detected. The most common fragrance substance is menthol (41.0%), followed by ethyl maltol (36.9%), linalool (31.1%), methylcyclopentanone (26.2%), β-adamantanone (18.9%), ethyl vanillin (18.0%), b-ionone (10.7%), acetylpyrazine and a-ionone (9.0%).

Finally, through comparison, it was found that all 122 analyzed supplementary liquid (liquid oil) samples had GHS classification as "additives with certain hazards/hazard levels".


● Methylcyclopentanone and α-ionone can cause allergy or asthma symptoms or difficulty breathing if inhaled;

● Methylcyclopentanone can also cause respiratory irritation;

● Acetylpyrazine, ethyl vanillin and menthol can cause irritation to the respiratory tract.

In addition to the substances that will irritate the respiratory tract in the above GHS classification, the remaining substances contain various warning effects, including skin, eye and respiratory tract irritation; allergies, harmful or even fatal swallowing; cause drowsiness or dizziness; suspected damage to fertility or fetus ; Toxicity to aquatic organisms; and Flammability.

Finally, the report concluded:

Chemicals and ultrafine particles in e-cigarette vapor can cause a dry cough in the pharynx and irritate the upper and lower respiratory systems, and it is also potentially toxic and carcinogenic.

In addition, it has been found that ethylene glycol and glycerin vapors and other mist components of e-cigarettes can cause dryness of the mucosa and irritate the upper respiratory tract.

The flavors used in e-cigarette liquid may also have an acute cytotoxic effect on respiratory tract cells, of which menthol, coffee and strawberry flavor will affect the overall cytotoxicity of the supplement liquid (liquid oil).

Electronic cigarette users are exposed to large amounts of benzaldehyde, which is a known respiratory irritant. Compared with other taste users, people who use cherry flavored electronic cigarette products may inhale higher doses of benzaldehyde.

The latest revision of the European Tobacco Product Directive (TPD) sets strong safety and quality standards for manufacturers and importers of e-cigarettes sold in the European Union to ensure a high level of health protection for European citizens. TPD stipulates that, with the exception of nicotine, the ingredients used in liquids containing nicotine must not pose a threat to human health in the form of heating or non-heating. With this in mind, the report believes that all e-cigarette products do not comply with the TPD standard.

Experts are angry: aside from the concentration, the toxicity is "rogue"!

Dr. Konstantinos Farsalinos, a well-known expert in the study of tobacco and e-cigarettes, and cardiology medicine expert, dismissed the research report that seemed to provide scientific evidence for "e-cigarette poisonous". He believed that although it was identified in the sample, it would affect the respiratory tract. Irritating substances, but this study did not publish calculation data related to the toxic concentration.

Translated, that is, the sentence we often hear, "Everything is a hooligan except for dosage and toxicity." Although there is also a general controversy in this sentence, Dr. Farsalinos means that the GHS classification corresponding to the substance that will stimulate the respiratory tract is found in the e-cigarette supplement liquid (liquid oil), but whether the concentration is It is not clear that it will cause harm to the human body, and the conclusion that e-cigarettes have potential health risks or even "carcinogenic" is completely irresponsible.

For example, potatoes contain aristolochic acid, tomatoes and eggplant contain nicotine. Aristolochic acid and nicotine are lethal toxic substances. Could it be said that potatoes, tomatoes, and eggplants are fatal? And use this to recommend the government Ban potatoes, tomatoes and eggplants?

Scientific "lie" needs science to debunk!

In order to test the "toxicity" of e-liquid, Dr. Farsalinos repeated this study and examined the toxicity classification of different chemicals at the maximum concentration in that study report.

Dr. Farsalinos and his team compared the concentration of each flavoring agent with the minimum concentration required for toxic substances in the GHS classification, and finally obtained the research data.

"In the test, it is concluded that the maximum concentration of these substances in the smoke oil is 71.6-99.9% lower than the toxic concentration" That is to say, most of the flavor compounds in the smoke oil are far less toxic than the minimum toxic level.

However, Dr. Farsalinos also mentioned an important point. Due to the different production processes and formulations of electronic cigarette oil, not all products have the same composition. For example, the toxicity of methylcyclopentenone in cigarette oil is 150.7 %.

Therefore, even if the toxicity of e-cigarette smoke oil is far lower than the minimum toxicity standard, the relevant departments must regularly monitor the composition of the smoke oil to avoid substandard and inferior products entering the market, and also urge users to choose regular brand products to avoid Purchase unused products from unconventional channels such as the black market.

What is methylcyclopentenone?

Methyl cyclopentenolone is a kind of food additive, abbreviated as: MCP, chemical name: 3-Methyl cyclopenten-1,2-dione (diketone structure); 2-Hydroxy-3-methyl-2-cyclopenten-1 -one (enol structure)

Function and use: Methyl cyclopentenolone (MCP) is a broad-spectrum food flavoring agent, and it is a edible flavor specified in GB2760-96 as permitted in my country.

Fragrant raw materials with nut-like and maple and walnut aromas can be used to prepare flavors and have a synergistic effect. It is used in the preparation of coffee, cocoa, chocolate, nuts, maple sugar, caramel and other flavors.

As a tobacco flavor, it can improve the flavor of tobacco leaves, improve the grade of tobacco leaves and the quality of cigarettes, and can be used as a modifier and a moderator.

Directly used in food, it can be used in conjunction with other fragrance raw materials, has the effect of flavor and sweetness, increase the variety of product colors, and also create good economic benefits for enterprises.

Widely used in walnuts and other nuts, syrups, rum sugar, caramel, scotch cream, spices, soups, wine, ice cream.

Excessive intake will produce dependence.

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