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Studies have shown that cannabinol CBD has a protective effect on Alzheimer's disease

2020/08/17|Knowledge

University College London researchers found that CBD can affect and promote brain blood flow, so as to achieve the goal of treating Alzheimer's disease (commonly known as Alzheimer's disease). Today, the inspector will present several top-level documents to prove the impact of CBD on diseases such as Alzheimer's disease.

This is the detective's 289 original

01. General

In the Journal of psychopharmacology published last week, University College London researchers were surprised to find that using CBD can boost blood flow to the brain, and that CBD can increase brain blood flow to key areas of memory processing, especially the hippocampus. This determines the potential therapeutic mechanism of CBD, that is, the effectiveness of treatment for diseases including Alzheimer's disease, schizophrenia, post-traumatic stress disorder, etc.

02. Hippocampus and Alzheimer's disease

Hippocampus

Hippocampus

The hippocampus is the organ responsible for storing short-term memory in the brain

It's a combination of neurons in the brain

It is named after the seahorse of the foreign minister

The normal brain will receive the external information to the hippocampus, forming a short-term memory. Due to the limited capacity, some information that has not been used for a period of time will be automatically deleted by the hippocampus to make room for new information. If some information is mentioned many times in a short time, it will be transferred from the hippocampus to the cerebral cortex, eventually forming long-term memory.

Alzheimer's disease (i.e. Alzheimer's disease) patients' problems appear in the hippocampus, for some reasons, the brain memory can not work properly, thus forming Alzheimer's disease.

Amyloid beta is an inactive protein. Its raw material is amino acid. Several amino acids are entangled to form amyloid beta protein. Its function and mission is to be processed into protein. However, there are some restless amyloid beta protein in the blood, cerebrospinal fluid, brain interstitial fluid flow around.

If these restless amyloid beta proteins accumulate in large quantities in the hippocampus, neurons in the hippocampus will not be able to breathe until they die. As a result, a large number of neurons in the hippocampus die, the function of the hippocampus is damaged, the hippocampus atrophy and so on, which leads to Alzheimer's disease and other neurodegenerative diseases. The volume of the hippocampus is directly related to human intelligence quotient. The inspector heard that Einstein and some other scientists' hippocampus even reached the pearl shape.

03. The latest research results

The gradual atrophy of hippocampus is the main cause of short-term memory loss in Alzheimer's disease, and CBD will play an important role in it, including the improvement of function and how the brain processes emotional memory, so as to achieve the purpose of remission or treatment by improving sleep.

Researchers at University College London used a randomized, crossover, double-blind design. In order to ensure the accuracy of the test CBD absorption data, participants began fasting within 12 hours. Then 15 healthy participants were given 600 mg of CBD or placebo, and regional cerebral blood flow (CBF) was measured 3 hours after administration.

The results show that

CBD caused a significant increase of CBF in hippocampus

The above image shows the difference of local CBF between CBD and placebo. Compared with placebo group, the mean blood flow in the inner temporal lobe and prefrontal cortex is also significantly different. The asterisk indicates the area where CBF changes significantly after many comparisons.

Placebo cbd

The above figure shows the difference of CBF in hippos after CBD or placebo

The above figure shows the differences of memory tasks after using CBD and placebo

The researchers believe that the exact mechanism of CBD in regulating memory processing is unclear. In addition to regulating the vascular system, CBD also has many neuronal targets, which may be the basis of its cognitive, anti anxiety and antipsychotic effects.

Hippocampus is an important therapeutic target for a variety of neuropsychiatric disorders. In addition to Alzheimer's disease, depression, PTSD and other diseases are closely related to regional cerebral blood flow and brain volume changes. Because CBD can increase the regional cerebral blood flow in the hippocampus, and Alzheimer's disease is mainly due to the defects of the hippocampus in the blood flow control, so this discovery proves that CBD can delay the atrophy of hippocampus and improve the scene and memory function, so as to delay or treat Alzheimer's disease.

Fultz et al.2019

In November 2019, science also published a study, and researchers at Boston University found a similar thing: the brain cleaning process.

In the image above, red is blood and blue is cerebrospinal fluid. Blood will flow out of the brain periodically and cerebrospinal fluid will take the opportunity to start a cleaning. The red cerebrospinal fluid (CSF) removes toxins, and the main toxin is amyloid beta as described above.

This cleaning can only be done after sleeping, so the team demonstrated why people wake up full of energy, that is, the toxins in the brain are removed. And not sleeping brain, cerebrospinal fluid is not enough to clean the brain, so people will feel particularly tired.

In another paper published by Bryce a Mander in the journal Nature, aging and local brain atrophy are also introduced, which are related to the decrease of slow wave activity during sleep. The slow wave loss is directly related to the CSF flow.

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