The trial consisted of a six week, placebo-controlled, randomized clinical trial of 255 adults seeking to quit smoking its (131 nicotine gum, 124 placebo). The researchers investigated the results of temptations with or without gum.
There were 2713 plots of temptation in the participants, 46.0% (1248), which led to smoking. The pooled data showed that compared with placebo, nicotine gum reduced the chance of overturning (or = 0.45, 0.22-0.94).
E-cigarettes are twice as efficient as other NRTs
Meanwhile, a 2019 randomized trial conducted by Queen Mary University in London, supported by the National Institutes of health, the health technology assessment program and cancer research in the UK, shows that e-cigarettes are almost twice as effective as other NRTs in quitting smoking.
Researchers followed nearly 900 smokers' attempts to quit smoking. All adults who visited the NHS smoking cessation clinic were randomly divided into two groups. One group received their choice of conventional nicotine replacement therapy (NRT), such as nicotine glue or patch (including product mix, if needed), while the other group received electronic cigarettes. In addition, behavioral support was provided to the two groups.
A year later, participants were assessed for smoking, including biochemical tests to ensure that those who claimed to quit did. In one year, the one-year withdrawal rate of NRT group reached 9.9%, which was a surprisingly high level, because previous studies found that the withdrawal rate of NRT was only 5-7%. However, the success rate of the e-cigarette group was almost twice that of the latter, with a moderation rate of 18%.